Jost offers Highly Bioavailable Magnesium Compounds for Supplements

Magnesium is a nutrient that is vital to energy supply and utilization in the body. It is required to help the body produce energy, including protein synthesis, muscle and nerve function, blood glucose control, and blood pressure regulation. Maintaining these functions is vital to several systems in the human body. Deficiencies lead to serious health issues.

Studies have shown that the average American male gets about three fourths of the RDI of magnesium eating a regular diet. Based on this knowledge alone, supplementation with dietary supplements containing magnesium seems crucial to maintaining good health¹. The Recommended Daily Intake (RDI) for magnesium (Mg) is 400 mg/day for adult males with slightly lower amounts for women and children.

Researchers have determined that lower levels of magnesium in the blood may lead to metabolic malfunctions such as diabetes. Researchers also have demonstrated that the impaired kidney function connected with diabetes might explain the higher levels of magnesium in the urine, which combined with insufficient magnesium intake, causes the high blood sugar levels associated with the disease. The mineral is required to facilitate energy production by the body and plays a critical role in function such as protein synthesis, muscle and nerve function, blood glucose control, and blood pressure regulation.

Magnesium is a vital nutrient and is the active mineral in at least 300 known enzymes in the human body^2,3,4. Magnesium is very important for heart function as it is known to be required for the electrical functions of the heart to keep a regular beat and for maintaining healthy blood pressures.

Further studies have shown that diabetics do not have enough of this vital mineral⁵ and that magnesium actually helps control blood glucose^6,7 and has been found to regulate and improve blood sugar control. It plays a vital role in the secretion and function of insulin and is necessary for insulin to open cell membranes for glucose and helps the body digest, absorb, and utilize proteins, fats, and carbohydrates.

Jost Chemical produces several magnesium compounds for supplementation that are chelated and offer high bioavailability, including^{8, 9, 10, 11, 12}:

• Magnesium citrate
• Magnesium lactate
• Magnesium gluconate
• Magnesium phosphate di- and tribasic
• Magnesium aspartate
• Magnesium malate
• Magnesium ascorbate
• Magnesium glycinate

Jost Chemical also produces magnesium sulfate, which is ionic and soluble and may not be as bioavailable. (It is more commonly used as a laxative.) As with all Jost Chemical products, the magnesium compounds are pure and follow the appropriate USP, NF, and FCC monographs.

Several of these salts are water soluble (aspartate, citrate, gluconate, lactate, ascorbate, and malate). These can be used where the end product is a liquid and needs solubility. The hydrated citrate and phosphates are insoluble and used more in dry powder or tableted products. When mixed with Ca Citrate salts, they tend to solidify in water solutions.

Jost has recently introduced magnesium glycinate (also known as magnesium bis-glycinate). Magnesium glycinate is a water-soluble magnesium salt that is known for delivery very high levels of magnesium absorption and bioavailability and is considered, by some experts, as one of the best-absorbed forms of this mineral and the most-gentle on the stomach¹³. Studies indicate that magnesium glycinate may promote better sleep as well¹⁴. Glycinate salts are derived from the nonessential amino acid called glycine that provides a calming effect on the brain. In a 2011 Journal of Pharmacological Sciences study, rats that were given glycine had higher plasma and cerebrospinal fluid glycine concentrations and experienced a reduction in core body temperature. Lower body temperatures are known to promote sleep¹⁵.

Jost has developed a unique calcium magnesium citrate co-salt using a proprietary process to produce. This co-salt contains calcium and magnesium in a 2:1 Ca:Mg molar ratio. The micronized product will prove beneficial to customers that desire aqueous suspensions of Ca and Mg with excellent mouth feel and unmatched suspension stability. It has been reported that dry blends of calcium citrate and magnesium citrate micronized powders combined and slurried in water (20 – 30% w/w) display extensive thickening, solidification and/or hardening. The two citrate salts react in the aqueous phase and precipitate a unique compound whose suspension is extremely thixotropic. This resulting mixture does not remain fluid and completely solidifies over time, providing difficult if not impossible dosing from the finished goods container. The solidification process is generally slow; however, experimental data demonstrates rapid acceleration of this reaction when heat (sterilization) is applied to the system. Jost’s calcium magnesium citrate co-salt stays in suspension and therefore alleviates solidification, hardening and flowability issues, even over an extended period of time.

Granular calcium magnesium citrate will be most beneficial to customers that desire a directly compressible magnesium source for tablet manufacturing. Typically, magnesium salts are very difficult to tablet. It is with great enthusiasm that we report the compressibility of calcium magnesium citrate co-salt exceeds that of Jost Chemical’s industry leading calcium citrate. Also noteworthy is the superior compression of calcium magnesium citrate compared to a dry blend of calcium citrate and magnesium citrate.

See a full list of Jost Magnesium product offerings here.

Read more about how Jost Chemical’s mineral salts, such as copper, iron, magnesium, manganese, and zinc, support healthy living—in this white paper: The Importance of Minerals in the Long Term Health of Humans.